NIZAR MAHMOUD ABDEL AZIZ AL-ZOU'BI

Nizar Mahmoud Abdel Aziz Al-Zou'bi	Professor
Pharmacy
Faculty of Pharmaceutical Sciences	Department of Pharmaceutics and Pharmaceutical Technology
nzoubi@hu.edu.jo	http://staff.hu.edu.jo/nizaralzoubi
ORCID ID : 158435830
Office No. : 482	EXT : 3440 , 3401

C.V. Document file as PDF:

Ph.D.	Aristotle University of Thessaloniki	Greece,2002
Master		,
Bachelor	Jordan University of Science and Technology	Jordan,1996

Controlled release of drugs from solid dosage forms:
   -Matrix systems prepared by direct compaction or via spray 
    drying  and other different techniques 
   -Multilayer tablets for release programming
Solid state properties of pharmaceutical materials: 
   -Solid-state modification and evaluation of pharmaceutical 
    materials
      -Development of methods for quantitative determination of 
       polymorphs in powder mixtures

 1.	Al-Akayleh, F., Alkhawaja, B., Al-Zoubi, N., Abdelmalek, S. M. A., Daadoue, S., AlAbbasi, D., Al-Masri, S., Agha, A. S., Alaa, A. R., Olaimat, A., Habashneh, L., Al-Remawi, M., & Woodman, T. (2025). Optimized ethylcellulose films incorporating a novel clotrimazole deep eutectic system for enhanced permeation and antifungal activity. International Journal of Pharmaceutics, 126207.
2.	Al-Zoubi, N. M., Mansi, I. A., Jaber, M. R., Abu-Alkebash, E. N., & Al-Hashimi, N. N. (2025). Hydrocolloid from leaves of Corchorus olitorius L. as a matrix former for oral controlled drug delivery: Investigation of swelling, release, and compression behaviors. International Journal of Biological Macromolecules, 145308.
3.	Abdel Rahim, S., Al-Zoubi, N., Gharaibeh, S., & Aljaberi, A. (2025). Kollidon® SR: Formulation techniques and drug delivery applications. International Journal of Pharmaceutics, 125078.
4.	Al-Akayleh, F., Alkhawaja, B., Al-Remawi, M., Al-Zoubi, N., Nasereddin, J., Woodman, T., Jaber, N., Ahmad, M. I., AbuQatouseh, L., Omari, D., & Agha, A. S. (2024). An investigation into the preparation, characterization, and therapeutic applications of novel gefitinib/capric acid deep eutectic systems. Journal of Pharmaceutical Innovation, 19(6), 79.
5.	Al-Akayleh, F., Alkhawaja, B., Al-Zoubi, N., Abdelmalek, S. M., Daadoue, S., AlAbbasi, D., Al-Masri, S., Agha, A. S., Olaimat, A. R., & Woodman, T. (2024). Novel therapeutic deep eutectic system for the enhancement of ketoconazole antifungal activity and transdermal permeability. Journal of Molecular Liquids, 125975.
6.	Abdel Rahim, S., Al-Zoubi, N., Khader, H., Alwaraydat, R., & Al-Akayleh, F. (2023). Ethanol-induced dose dumping from sodium alginate matrix tablets: Investigation of the effects of medium viscosity and pH. International Journal of Pharmaceutics, 122568.
7.	Gharaibeh, S., Obeidat, W., & Al-Zoubi, N. (2022). Effect of post-compaction heating on characteristics of microcrystalline cellulose compacts. e-Polymers, 22, 536–543.
8.	Al-Zoubi, N., Partheniadis, I., Aljaberi, A., & Nikolakakis, I. (2022). Co-spray drying drugs with aqueous polymer dispersions (APDs)—A systematic review. AAPS PharmSciTech, 23, 1–9.
9.	Aljaberi, A., Migdadi, E. M., Abu Khadra, K. M., Abu Samak, M., Basheti, I. A., & Al-Zoubi, N. (2022). siRNA as a potential therapy for COVID-19. Current Drug Delivery.
10.	Partheniadis, I., Nikolakakis, I., Zacharis, C. K., Kachrimanis, K., & Al-Zoubi, N. (2021). Co-spray drying of paracetamol and propyphenazone with polymeric binders for enabling compaction and stability improvement in a combination tablet. Pharmaceutics, 13(8), 1259.
11.	Al-Zoubi, N., Gharaibeh, S., Aljaberi, A., & Nikolakakis, I. (2021). Spray drying for direct compression of pharmaceuticals. Processes, 9(2), 267.
12.	Al-Zoubi, N., Odeh, F., Gharaibeh, S., Partheniadis, I., & Nikolakakis, I. (2021). Spray drying of naproxen and naproxen sodium for improved tableting and dissolution: Physicochemical characterization and compression performance. Pharmaceutical Development and Technology, 26(2), 193–208.
13.	Al-Zoubi, N., Ardakani, A., Odeh, F., Sakhnini, N., Partheniadis, I., & Nikolakakis, I. (2020). Mechanical properties of starch esters at particle and compact level: Comparisons and exploration of the applicability of Hiestand’s equation to predict tablet strength. European Journal of Pharmaceutical Sciences, 147, 105292.
14.	Partheniadis, I., Karantzalis, A. E., Shah, R. R., Al-Zoubi, N., & Nikolakakis, I. (2020). Influence of compression at elevated temperature on the compactibility of thermo-mechanically processed polymers. Chemical Engineering Research and Design, 156, 64–75.
15.	Sanoufi, M., Aljaberi, A., Hamdan, I., & Al-Zoubi, N. (2020). The use of design of experiments to develop hot melt extrudates for extended release of diclofenac sodium. Pharmaceutical Development and Technology, 25, 187–196.
16.	Al-Zoubi, N., Al-Rusasi, A., & Sallam, A. (2019). Ethanol effect on acid resistance of selected enteric polymers. Pharmaceutical Development and Technology, 24(1), 24–34.
17.	Al-Zoubi, N., Odah, F., Obeidat, W., Al-Jaberi, A., Partheniadis, I., & Nikolakakis, I. (2018). Evaluation of spironolactone solid dispersions prepared by co-spray drying with Soluplus® and polyvinylpyrrolidone and influence of tableting on drug release. Journal of Pharmaceutical Sciences, 107(9), 2385–2398.
18.	Al-Hashimi, N., Aleih, H., Al-Zoubi, N., & Hamed, S. (2018). Solid bar microextraction and HPLC/DAD determination of diuretic drugs and its application to spiked human urine. Jordan Journal of Pharmaceutical Sciences, 11(1), 39–53.
19.	Al-Zoubi, N., Odeh, F., & Nikolakakis, I. (2017). Co-spray drying of metformin hydrochloride with polymers to improve compaction behavior. Powder Technology, 307, 163–174.
20.	Al-Zoubi, N., Al-Obaidi, G., & Tashtoush, B., Malamataris, S. (2016). Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP. Drug Development and Industrial Pharmacy, 42, 270–279.
21.	Al-Zoubi, N., Alkhatib, H. S., Alobaidi, G., Abdel Rahim, S., Obeidat, W., & Malamataris, S. (2015). Optimization of pH-independent chronotherapeutic release of verapamil HCl from three-layer matrix tablets. International Journal of Pharmaceutics, 494, 296–303.
22.	Sakhnini, N., Al-Zoubi, N., Alobaidi, G., & Ardakani, A. (2015). Sustained release matrix tablets prepared from co-spray dried mixtures with starch hydrophobic esters. Pharmazie, 70, 177–182.
23.	Al-Zoubi, N., & Gharaibeh, S. (2014). Compaction behavior of metformin HCl powders obtained by combined cooling anti-solvent crystallization. Jordan Journal of Applied Sciences, 12, 39–46.
24.	Obeidat, W., & Al-Zoubi, N. (2014). Controlled-release cellulose ester matrices for water-soluble diclofenac sodium: Compression and dissolution studies. Pharmazie, 69, 96–103.
25.	Aljaberi, A., Ardakani, A., Khdair, A., Alian, S., Meqdadi, E., Ayyash, M., Alobaidi, G., & Al-Zoubi, N. (2013). Tableting functionality evaluation of Prosolv Easytab in comparison to physical mixtures of its individual components. Journal of Drug Delivery Science and Technology, 23, 499–504.
26.	Abdel Rahim, S., Al-Ghazawi, M., & Al-Zoubi, N. (2013). Influence of ethanol on swelling and release behavior of Carbopol®-based tablets. Pharmaceutical Development and Technology, 18, 1089–1100.
27.	Ardakani, A., Al-Zoubi, N., Sakhnini, N., & Taha, O. (2013). Synthesis of a novel chitosan-based polymer and application as a matrix for controlled drug delivery. Jordan Journal of Pharmaceutical Sciences, 6, 233–240.
28.	Al-Zoubi, N., Al-Khatib, H., & Obeidat, W. (2011). Evaluation of hydrophilic matrix tablets based on Carbopol® 971P and low-viscosity sodium alginate for pH-independent controlled drug release. Drug Development and Industrial Pharmacy, 37, 798–808.
29.	Al-Zoubi, N., Kachrimanis, K., Malamataris, S., & Younis, K. (2011). Optimization of extended-release hydrophilic matrix tablets by support vector regression (SVR). Drug Development and Industrial Pharmacy, 37, 80–87.
30.	Obeidat, W., Obeidat, S., & Al-Zoubi, N. (2009). Investigations on the physical structure and mechanism of drug release from enteric matrix microspheres with near-zero-order release kinetics using SEM and quantitative FTIR. AAPS PharmSciTech, 10(2), 615–623.
31.	Al-Zoubi, N., & Malamataris, S. (2008). Three-layer matrix tablets and simple approach of drug release programming. Journal of Drug Delivery Science and Technology, 18, 431–437.
32.	Al-Zoubi, N., Al-Khatib, H., Bustanji, Y., Aiedeh, K., & Malamataris, S. (2008). Sustained release of buspirone HCl by co-spray drying with aqueous polymeric dispersions. European Journal of Pharmaceutics and Biopharmaceutics, 69, 735–742.
33.	Aiedeh, K. M., Al-Khatib, H., Taha, M. O., & Al-Zoubi, N. (2006). Application of novel chitosan derivatives in dissolution enhancement of a poorly water-soluble drug. Pharmazie, 61, 306–311.
34.	Al-Zoubi, N., & Malamataris, S. (2003). Effect of initial concentration and seeding procedure on crystallization of orthorhombic paracetamol from ethanolic solution. International Journal of Pharmaceutics, 260, 123–135.
35.	Al-Zoubi, N., Kachrimanis, K., & Malamataris, S. (2002). Effect of harvesting and cooling on crystallization and transformation of orthorhombic paracetamol in ethanolic solution. European Journal of Pharmaceutical Sciences, 17, 13–21.
36.	Al-Zoubi, N., Kondourellis, I., & Malamataris, S. (2002). FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes. Journal of Pharmaceutical and Biomedical Analysis, 29, 459–467.
37.	Al-Zoubi, N., Nikolakakis, I., & Malamataris, S. (2002). Crystallization conditions and formation of orthorhombic paracetamol from ethanolic solution. Journal of Pharmacy and Pharmacology, 54, 325–333.

1) Ahmad Oglah Al-Rusasi, Influence of ethanol on acid resistance of some enteric film coating polymers, Defended: May, 2015, Faculty of Pharmacy, Applied Science University.

2) Faten Omar Odeh, Coprocessing via spray drying to improve compression behavior of metformin hydrochloride, Defended: January, 2015, Faculty of Pharmacy, Applied Science University.

 3) Safwan Abdel Rahim, The influence of ethanol on swelling of Carbopol® and release of model drugs from its matrix systems, Defended: May, 2010, Faculty of Pharmacy, The University of Jordan.

2023 – present	Professor, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University
2022 – 2023	Visiting professor, Department of Pharmacy, Faculty of Pharmacy, Jerash University
2020 – present	Professor, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University
2018 – 2022	Dean, Faculty of Pharmaceutical Sciences, The Hashemite University
2017 – 2018	Vice Dean, Faculty of Pharmaceutical Sciences, The Hashemite University
2014 – 2020	Associate Professor, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University
2009 – 2014	Associate Professor, Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University.


2008 – 2014 	Head of Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University.


2002 – 2009	Assistant Professor, Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University.


1996 – 1999	Pharmacist, Quality department in Middle East Pharmaceutical and Chemical Industries & Medical Appliances Co.

  Undergraduate Courses:	
Industrial Pharmacy I & II (Theoretical and practical courses) 
Advanced Industrial Pharmacy
Development and production of Pharmaceuticals 
Pharmaceutics I & II (Theoretical and practical courses)
Pharmaceutical Calculations and compounding (Theoretical and practical courses)
Physical Pharmacy I & II (Theoretical and practical courses) 
Pharmaceutical Legislation 
Pharmaceutical Quality and Regulatory affairs
Radioactive Pharmaceutical Preparations
Specialized Field Training in Industrial Pharmacy

Postgraduate courses:
Advanced Pharmaceutical Technology
Advanced Drug Delivery Systems
Advanced Physical Pharmacy
Research Methodology
Research Project

 Member of the International Pharmaceutical Federation (FIP).
•	Member of the Jordanian Pharmaceutical Association.
•	Member in the working group for revising drugs registration criteria, Jordan Food and Drug Administration (JFDA), March-2006.
•	Member of drug re-registration committee, JFDA (2010-2012)
•	Member of inspection committee, JFDA (2012-2014)

 Reviewer for the following international journals:
•	AAPS PharmSciTech
•	Applied Food Research
•	Current Drug Delivery
•	Drug Development and Industrial Pharmacy
•	European Journal of Pharmaceutics and Biopharmaceutics
•	European Journal of Pharmaceutical Sciences
•	Expert Opinion on Drug Delivery
•	Gels
•	International Journal of Pharmaceutics
•	Jordan Journal of Pharmaceutical Sciences 
•	Journal of Drug Delivery Science and Technology
•	Journal of Molecular liquids
•	Journal of Pharmaceutical Sciences
•	LWT 
•	Pharmaceutical Development and Technology
•	Pharmaceuticals
•	Pharmaceutics
•	Powder Technology
•	Processes
•	Scientific Reports

NIZAR MAHMOUD ABDEL AZIZ AL-ZOU'BI

NIZAR MAHMOUD ABDEL AZIZ AL-ZOU'BI

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