NIZAR MAHMOUD ABDEL AZIZ AL-ZOU'BI

Nizar Mahmoud Abdel Aziz Al-Zou'bi	Professor
Pharmacy
Faculty of Pharmaceutical Sciences	Department of Pharmaceutics and Pharmaceutical Technology
nzoubi@hu.edu.jo	http://staff.hu.edu.jo/nizaralzoubi
ORCID ID : 158435830
Office No. : 482	EXT : 3440 , 3401

C.V. Document file as PDF:

Ph.D.	Aristotle University of Thessaloniki	Greece,2002
Master		,
Bachelor	Jordan University of Science and Technology	Jordan,1996

Controlled release of drugs from solid dosage forms:
   -Matrix systems prepared by direct compaction or via spray 
    drying  and other different techniques 
   -Multilayer tablets for release programming
Solid state properties of pharmaceutical materials: 
   -Solid-state modification and evaluation of pharmaceutical 
    materials
      -Development of methods for quantitative determination of 
       polymorphs in powder mixtures

 1.	Rahim, Safwan Abdel, Nizar Al-Zoubi, Heba Khader, Rahaf Alwaraydat, and Faisal Al-Akayleh. "Ethanol-induced dose dumping from sodium alginate matrix tablets: Investigation of the effects of medium viscosity and pH." International Journal of Pharmaceutics (2023): 122568.
2.	Gharaibeh Shadi, Obeidat, Wasfy, Al-Zoubi, Nizar. " Effect of post-compaction heating on characteristics of microcrystalline cellulose compacts " e-Polymers 2022:22, 536-543.
3.	Al-Zoubi, Nizar, Partheniadis, Ioannis, Ahmad Aljaberi, and Ioannis Nikolakakis. " Co?spray Drying Drugs with Aqueous Polymer Dispersions (APDs)—a Systematic Review" AAPS PharmSciTech  2022: 23, 1 – 9.
4.	Aljaberi, Ahmad, Eman M. Migdadi, Khalid M. Abu Khadra, Mahmoud Abu Samak, Iman A. Basheti, and Nizar Al-Zoubi. "siRNA as a potential therapy for COVID-19." Current Drug Delivery (2022).
5.	Partheniadis, Ioannis, Nikolakakis Ioannis, Zacharis Constantinos K., Kachrimanis Kyriakos, and Al-Zoubi Nizar. "Co-Spray Drying of Paracetamol and Propyphenazone with Polymeric Binders for Enabling Compaction and Stability Improvement in a Combination Tablet." Pharmaceutics 13, no. 8 (2021): 1259.
6.	Al-Zoubi, Nizar, Shadi Gharaibeh, Ahmad Aljaberi, and Ioannis Nikolakakis. "Spray Drying for Direct Compression of Pharmaceuticals." Processes 9, no. 2 (2021): 267.
7.	Nizar Al-Zoubi, Faten Odeh, Shadi Gharaibeh, Ioannis Partheniadis, Ioannis Nikolakakis, Spray drying of naproxen and naproxen sodium for improved tableting and dissolution – physicochemical characterization and compression performance, Pharmaceutical Development and Technology, 26, no. 2 (2021): 193-208.
8.	Nizar Al-Zoubi, Adel Ardakani, Faten Odeh, Nina Sakhnini, Ioannis Partheniadis, Ioannis Nikolakakis, Mechanical properties of starch esters at particle and compact level - Comparisons and exploration of the applicability of Hiestand’s equation to predict tablet strength, European Journal of Pharmaceutical Sciences, 2020:147, 105292.
9.	Partheniadis I., Karantzalis A.E., Shah R.R., Al-Zoubi N., Nikolakakis I. Influence of compression at elevated temperature on the compactibility of thermo-mechanically processed polymers. Chemical Engineering Research and Design. 2020:156, 64-75.
10.	Sanoufi M., Aljaberi A, Hamdan I., Al-Zoubi N. The use of design of experiments to develop hot melt extrudates for extended release of diclofenac sodium, Pharmaceutical Development and Technology, 2020:25,187-196.
11.	Al-Zoubi, N., Al-Rusasi, A., Sallam, A. Ethanol effect on acid resistance of selected enteric polymers.  Pharmaceutical development and technology, 2019: 24(1), 24-34 
12.	Al-Zoubi, N., Odah, F., Obeidat, W., Al-Jaberi, A., Partheniadis, I., Nikolakakis, I. Evaluation of Spironolactone Solid Dispersions Prepared by Co-Spray Drying With Soluplus® and Polyvinylpyrrolidone and Influence of Tableting on Drug Release. Journal of pharmaceutical sciences, 2018:107(9), 2385-2398. 
13.	AL-Hashimi, N., Aleih, H., Al-Zoubi, N., Hamed, S. Solid Bar Microextraction and HPLC/DAD Determination of Diuretic Drugs and its Application to Spiked Human Urine. Jordan Journal of Pharmaceutical Sciences, 2018: 11(1), 39-53.
14.	Al-Zoubi N, Odeh F, Nikolakakis I, Co-spray drying of metformin hydrochloride with polymers to improve compaction behavior. Powder Technology, 2017. 307: 163-174. 
15.	Al-Zoubi N, Al-obaidi G, Tashtoush B, Malamataris S, Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP, Drug Development and Industrial Pharmacy 2016. 42: 270-279. 
16.	Al-Zoubi, N., Alkhatib, H. S., Alobaidi, G., Abdel-Rahim, S., Obeidat, W., Malamataris, S. Optimization of pH-independent chronotherapeutic release of verapamil HCl from three-layer matrix tablets. International Journal of Pharmaceutics 2015. 494, 296-303. 
17.	Sakhnini N, Al-Zoubi N,  Alobaidi G, Ardakani A. Sustained release matrix tablets prepared from cospray dried mixtures with starch hydrophobic esters, Pharmazie, 2015. 70: 177–182 
18.	Al-Zoubi N, Gharaibeh S. Compaction behavior of metformin HCl powders obtained by combined cooling anti-solvent crystallization, Jordan Journal of Applied Sciences, 2014. 12: 39-46.
19.	Obeidat W, Al-Zoubi N. Controlled-release cellulose esters matrices for water-soluble diclofenac sodium: compression and dissolution studies, Pharmazie, 2014 69: 96–103. 
20.	Aljaberi A, Ardakani A, Khdair A, Alian S, Meqdadi E, Ayyash M, Alobaidid G, Al-Zoubi N. Tabletting functionality evaluation of Prosolv Easytab in comparison to physical mixtures of its individual components, Journal of Drug Delivery Science and Technology, 2013. 23: 499-504. 
21.	Abdel Rahim S, Al-Ghazawi M, Al-Zoubi N. Influence of ethanol on swelling and release behavior of Carbopol®-based tablets, Pharmaceutical Development and Technology, 2013. 18: 1089-1100. 
22.	Ardakani A, Al-Zoubi N, Sakhnini N, Taha O. Synthesis of a novel chitosan-based polymer and application as a matrix for controlled drug delivery. Jordan Journal of Pharmaceutical Sciences, 2013. 6:233-240.
23.	Al-Zoubi N, AlKhatib H, Obeidat W. Evaluation of hydrophilic matrix tablets based on Carbopol® 971P and low-viscosity sodium alginate for pH-independent controlled drug release. Drug Development and Industrial Pharmacy. 2011. 37: 798–808. 
24.	Al-Zoubi N, Kachrimanis K, Malamataris S, Younis K. Optimization of extended-release hydrophilic matrix-tablets by Support Vector Regression (SVR). Drug Development and Industrial Pharmacy. 2011. 37: 80-87. 
25.	Obeidat, W., Obeidat, S., AlZoubi, N., Investigations on the physical structure and the mechanism of drug release from an enteric matrix microspheres with a near-zero-order release kinetics using SEM and quantitative FTIR, 2009, AAPS PharmSciTech, 10(2):615-23. 
26.	Al-Zoubi, N. Malamataris, S. Three-layer matrix tablets and simple approach of drug release programming, 2008, Journal of Drug Delivery Science and Technology 18, 431-437. 
27.	Al-Zoubi, N. Al-Khatib, H. Bustanji, Y. Aiedeh, K. Malamataris, S. Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions, European Journal of Pharmaceutics and Biopharmaceutics. 2008, 69, 735-742. 
28.	Aiedeh K.M., Al-Khatib H., Taha M.O., Al-Zoubi N. Application of novel Chitosan derivatives in dissolution enhancement of a poorly water soluble drug, Pharmazie, 2006, 61, 306-311. 
29.	Al-Zoubi N., Malamataris S. Effect of initial concentration and seeding procedure on crystallisation of orthorhombic paracetamol from ethanolic solution. International Journal of Pharmaceutics, 2003, 260: 123 –135. 
30.	Al-Zoubi N., Kachrimanis K., Malamataris S. Effect of harvesting and cooling on crystallisation and transformation of orthorhombic paracetamol in ethanolic solution. European Journal of Pharmaceutical Sciences, 2002, 17: 13 –21. 
31.	Al-Zoubi N., Kondourellis I., Malamataris S. FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes. Journal of Pharmaceutical and Biomedical Analysis, 2002, 29: 459–467. 
32.	Al-Zoubi N., Nikolakakis I., Malamataris S. Crystallisation conditions and formation of orthorhombic paracetamol from ethanolic solution. Journal of Pharmacy and Pharmacology, 2002,  54: 325–333.

1) Ahmad Oglah Al-Rusasi, Influence of ethanol on acid resistance of some enteric film coating polymers, Defended: May, 2015, Faculty of Pharmacy, Applied Science University.

2) Faten Omar Odeh, Coprocessing via spray drying to improve compression behavior of metformin hydrochloride, Defended: January, 2015, Faculty of Pharmacy, Applied Science University.

 3) Safwan Abdel Rahim, The influence of ethanol on swelling of Carbopol® and release of model drugs from its matrix systems, Defended: May, 2010, Faculty of Pharmacy, The University of Jordan.

2014 – now	Associate Professor, Faculty of Pharmaceutical Sciences, Hashemite University

2009 – 2014	Associate Professor, Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University.


2008 – 2014 	Head of Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University.


2002 – 2009	Assistant Professor, Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University.


1996 – 1999	Pharmacist, Quality department in Middle East Pharmaceutical and Chemical Industries & Medical Appliances Co.

  Undergraduate Courses:	
Industrial Pharmacy I & II (Theoretical and practical courses) 
Advanced Industrial Pharmacy 
Pharmaceutics I & II (Theoretical and practical courses)
Physical Pharmacy I & II (Theoretical and practical courses) 
Pharmaceutical Legislation 
Radioactive Pharmaceutical Preparations.

Postgraduate courses:
Advanced Pharmaceutical Technology

 Member of the International Pharmaceutical Federation (FIP).
•	Member of the Jordanian Pharmaceutical Association.
•	Member in the working group for revising drugs registration criteria, Jordan Food and Drug Administration (JFDA), March-2006.
•	Member of drug re-registration committee, JFDA (2010-2012)
•	Member of inspection committee, JFDA (2012-2014)

 Reviewer for the following international journals:
•      AAPS PharmSciTech
•	Current Drug Delivery
•	Drug Development and Industrial Pharmacy
•	European Journal of Pharmaceutics and Biopharmaceutics
•	Expert Opinion on Drug Delivery
•	International Journal of Pharmaceutics
•	Jordan Journal of Pharmaceutical Sciences 
•	Journal of Drug Delivery Science and Technology
•	Pharmaceutical Development and Technology
•	Powder Technology

NIZAR MAHMOUD ABDEL AZIZ AL-ZOU'BI

NIZAR MAHMOUD ABDEL AZIZ AL-ZOU'BI

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