KAYED ABED ALFATTAH ZAPEN ABUSAFIEH

Kayed A Z. Abu Safieh	Professor
Organic Chemistry-Heterocyclic Chemistry	Organic Chemistry
Faculty of Science	Department of Chemistry
kayedas@HU.EDU.JO	http://staff.hu.edu.jo/kayed
ORCID ID : 19810198
Office No. : 207	EXT : 4499

C.V. Document file as PDF:

Ph.D.	University of Jordan	Jordan,2000
Master	University of Jordan	Jordan,1985
Bachelor	University of Jordan	Jordan,1982

1. Natural Products Chemistry.
2. Synthesis of Bioactive Heterocyclic Compounds.

 1.	K. Abu Safieh, D. M. Al-Eisawi , M. H. Abu Zarga and S. S. Sabri, Chemical Constituents of the Flora of Jordan (II)- Alkaloids of Leontice Leontopetalum., J. of Natural Products, 49, 726 (1986). DOI:10.1021/np50046a044 , lnp50046a044
2.	Kayed A. Abu Safieh, Mustafa M. El-Abadelah, Salim S. Sabri, Musa H. Abu Zarga, Wolfgang Voelter and C?cilia M.-M?ssmer, Synthesis of Pyrazole-fused Azepino[5,4,3-cd]indoles, J. Heterocyclic Chem., 38, 623 (2001), DOI:10.1002/jhet.5570390133, jhet.5570390133
3.	Kayed A. Abu-Safieh, Mustafa M. El-Abadelah, Salim S. Sabri, Wolfgang Voelter, C?cilia M.-M?ssmer and Markus Stroebele, Bischler-Naprielski Synthesis of Some New Pyrazole-Fused  ?-Carbolines, Z. Naturforsch, 57b, 1327 (2002),   s57b1327.pdf 
4.	Basem A. Moosa,Kayed A. Abu Safieh, and Mustafa M. El-Abadelah, Synthesis of Some Thiophene-Fused Azepino[5,4,3-cd]indoles, Heterocycles, 57 (10), 1831 ( 2002), DOI: 10.3987/COM-02-9551
    abst/00773
5.	Peter Gmeiner, Harald Hübner, Kayed A. Abu Safieh, Ismail I. Fasfous, Mustafa M. El-Abadelah, Salim S. Sabri, and Wolfgang Voelter , Synthesisand Dopamine Receptor Bindingof SomePyrazolo[3',4':6,7]Azepino[5,4,3-cd]Indoles, Heterocycles, 60 (6), 1339 (2003), DOI: 10.3987/COM-03-9734,  abst/01044
6.	Ibrahim Izeddina, Kayed Abu-Safieh, Mikdad  T. Ayoub, and Mohammad S. Mubarak, Synthesis and Characterization of Some New Pentadienoic Acid Derivatives, J. Saudi Chem. Soc., 9(1), 151 (2005) 
7.	Raid J. Abdel-Jalil, Monther Khanfar, Kayed Abu-Safieh,Samer Al-Gharabli, Mustafa El-Abadelah, and Wolfgang Voelter;An Efficient One-Pot Synthesisof Pyrazolopyrimidines, Intermediatesfor Potential Phosphodiesterase Inhibitors, Monatshefte f?r Chemie, 136, 619 (2005). 
      DOI: 10.1007/s00706-004-0252-0,   s00706-004-0252-0
8.	Musa I. El-Barghouthi, Kayed A. Abu-Safieh , Mikdad T. Al Arif and Mohammad S. Mubarak, Ring Substitutional Requirement for Biological Activity of 5-Aryl-3-Alkoxy-(2E,4E)-2,4-Pentadienoic Acids as New Growth Regulators.Theoretical Treatment, J. Saudi Chem. Soc.,11(2), 341 (2007).
9.	Kayed A. Abu Safieh,Ahmad M. Abu Mahthieh, Mustafa M. El-Abadelah, Mikdad T. Ayoub, and  Wolfgang  Voelter, Synthesis of 5-Substituted 1,3-Dimethylpyrazolo[4,3-e]-[1,2,4]triazines, Monatshefte fur Chemie, 138, 157 (2007), DOI: 10.1007/s00706-006-0583-0,
     s00706-006-0583-0
10.	Kayed A. Abu-Safieh, Monther Khanfer, Rawhi Al-Far, Basem Fares Ali, C. Maichle-Moessmer and Ahmad Abu-Rayyan, 5-Hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole, Acta Cryst.,E63, o3814(2007)
   DOI: 10.1107/S1600536807039517,  S1600536807039517
11.	Kayed A. Abu Safieh, Fouad H. Darras, Mikdad T. Ayoub, Mustafa M. El-Abadelah,  Salim S. Sabri and Wolfgang Voelter, Synthesis  of  8-substituted  12-methyl-12H-Imidazo[4',5': 2, 3][1,4]diazepino[6,7,1-jk]carbazoles, Heterocycles ,71(12), 2681 (2007), DOI: 10.3987/COM-07-11162,  abst/02477
12.	Monther A. Khanfar, Kayed A. Abu-Safieh, Rawhi Al-Far, Basem Fares Ali, C. Maichle-Moessmer, (E)-N'-[(Furan-2-yl)methylene]-2-hydroxy-2,2-diphenylacetohydrazidemonohydrate, Acta Cryst., E63, o4078(2007),DOI:10.1107/S1600536807044443, S1600536807044443
13.	 Kayed A. Abu Safieh, Basem A. Moosa, Mustafa M. El-Abadelah, Salim S. Sabri, and Wolfgang Voelter,Pictet-Spengler Synthesis of some Thiophene [c]-Fused ?-Carbolines, Monatshefte fur Chemie, 139,147 (2008) DOI: 10.1007/s00706-007-0763-6,  s00706-007-0763-6
14.	Kayed A. Abu Safieh, Ahmad M. S. Al-Titi, Jalal A. Zahra, and Mikdad T. Ayoub, Oxidative Cyclization of Arylidene Carboxyhydrazides: Synthesis of Substituted Hydroxydiphenylmethyl-1,3,4-oxadiazoles, Jordan Journal of Chemistry, 2(3),211 (2007),      JJC15-5-007Mod11-11- 2007.pdf
15.	Kayed A. Abu-Safieh, Monther A. Khanfar, Klaus Eichle and Basem FaresAli, 4-(4-Chlorophenyl)-1-(2-hydroxy-2,2-diphenylacetyl)-thiosemicarbazide, Acta Cryst.,E64, o2305 (2008), DOI: 10.1107/S1600536808035964, hk2559
16.	E. Y. Qnais, Kayed A. Abu-Safieh, Mohammad H. Abu-Diehand Fouad A. Abdulla, Antinociceptive effect of two flavonoids from Aloysia trphylla L., Jordan Journal of Biological Sciences, 2(4), 167 (2009), jjbs. /Aloysia_triphylla.pdf
17.	Adnan S. Abu-Surrah, Kayed A. Abu Safieh, Iman M. Ahmad, Maher Y. Abdalla, Mikdad T. Ayoub, Abdussalam K. Qaroush, Ahmad M. Abu-Mahtheieh, New palladium(II) complexes bearing pyrazole-based Schiff base ligands: Synthesis, characterization and cytotoxicity, European Journal of Medicinal Chemistry, 45, 471 (2010), DOI: 10.1016/j.ejmech.2009.10.029, S0223523409005315 
18.	Asma’a A. Al-Rifai, Mikdad T. Ayoub, Ashok K. Shakya, Kayed A. Abu Safieh and Mohammad S. Mubarak, Synthesis, characterization, and antimicrobial activity of some new coumarin derivatives, Med. Chem. Res., 21:468 (2012), DOI:10.1007/s00044-011-9553-0, 
   s00044-011-9553-0
19.	Kayed A. Abu Safieh, Feda'a S. Al-Masri, Mikdad T. Ayoub MustafaM. El-Abadelah and Wolfgang Voelter, Synthesis of Some 1,3-Dimethyl-6-substituted-1,4-dihydro-5H- Pyrazolo[3,4-b]Pyrazin-5-ones, Zeitschrift fuer Naturforschung, 66, 1136 (2011), 66b1136.pdf
20.	Bader A. Salameha,  Kayed A. Abu-Safieh,  Raed A. Al-Qawasmeh and Sanaa R. A. AL-Kaabenaha, Synthesis and characterization of new N-Phenylmaleimide Thioglycosides, Research on Chemical Intermediates, Published online: 23 March 2013, DOI: 10.1007/s11164-013-1146-8,    s11164-013-1146-8
21.	Mahmoud Sunjuk, Adnan S. Abu–Surrah, Kayed A. Abu Safieh,
    Abdussalam K. Qaroush, and  Feda'a M. Al-Qaisee,  ?- Diimine   palladium(II) based complexes mediated  polymerization of methyl methacrylate, Arabian Journal of Chemistry,  Published online: 14 March 2013, DOI: 10.1016/j.arabjc.2013.02.019, S1878535213000658
22.	Kayed A. Abu Safieh, Ala’a K. Hasan, Mikdad T. Ayoub and Mohammad S. Mubarak, Preparation of some alkenoic acid derivatives as new plant growth regulators,  Research on Chemical Intermediates, 
41,1863 (2015), DOI 10.1007/s11164-013-1315-9
s11164-013-1315-9
23.	Kayed A. Abu-Safieh, Monther A. Khanfar, Musa I. El-Barghouthi and Basem F. Ali,  Molecular Structure and Density Functional Theory Calculations of 3-(3-Nitrothien-2-yl)indole: Structural and Vibrational Analysis, Journal of Chemical Crystallography,4 , 330 (2014),  DOI 10.1007/s10870-014-0519-1
24.	Kayed A. Abu Safieh,  Manal M.Al-Oqal,  Mikdad T. Ayoub, and Muhannad  I. Massadeh, Synthesis, Characterization and Antimicrobial Activity of Some 5-Aryl-(2E,4E)-Pentadienoic Acid Derivatives,   Journal of Chemical, Biological and Physical Sciences, Section A: Chemical Sciences, 4 (3), 1927 (2014)

25.	Abdullah I. Saleh, Kayed A. Abu-Safieh, Bader A. Salameh, 
A Concise Route to 4-Aminomethylpyrazoles and 1 4- Aminomethyl-isoxazoles from Acetylacetone-derived Hexahydropyrimidines under Mild Conditions, Chemical Papers, 69 (5), 729 (2015), DOI: 10.1515/chempap-2015-0018 

26.	Kayed A. Abu Safieh, Yahya S. Al-Degs, Mahmoud S. Sunjuk, Abdulah I. Saleh, Mohammad A. Al-Ghouti, Selective Removal of Dibenzothiophene from Commercial Diesel Using Manganese Dioxide Modified Activate Carbon: A Kinetic Study, Environmental Technology, 36 (1), 98 ( 2014),  DOI: 10.1080/09593330.2014.938125, 09593330.2014.938125

27.	 R. Z. Al Bakain , Y. S. Al-Degs, A. Issa, S. Abdul Jawad , K. A. Abu   Safieh and M. A. Al-Ghouti,  Activation of Kaolin with Minimum Solvent Consumption by Heating, Clay Minerals, 49, 667 (2014), DOI: 10.1180/claymin.2014.049.5.04, claymin49/5/667
28.	Kayed A. Abu Safieh, Adnan S. Abu-Surrah, Hani D. Tabba, Huda A. AlMasri, Randa M. Bawadi, Fadila M. Boudjelal and Lubna H. Tahtamouni , Novel palladium(II) and platinum(II) complexes with a fluoro piperazinyl based ligand exhibiting high cytotoxicity and anticancer activity in vitro, Journal of Chemistry, Volume 2016, Article ID 7508724, http://dx.doi.org/10.1155/2016/7508724, 
http://www.hindawi.com/journals/jchem/2016/7508724

29.	Samir Bondock, Omeer Albormani, Ahmed M. Fouda and  Kayed A. Abu Safieh ,  Progress in the chemistry of 5-acetylthiazoles, Synthetic Communications, 46:13, 1081-1117 (2016), DOI: 10.1080/00397911.2016.1180700, http://dx.doi.org/10.1080/00397911.2016.1180700

 Selected Supervised Graduates
1.Ahmad M. S. Al-Titi
Synthetic routes to substituted azoles: Synthesis of benzilate derivative
2. Ahmad M. Abu Mahthieh
Synthesis of New   Polyfunctionally Substituted Pyrazolotriazines
3.Fouad H. Darras
Syntheses and reactions of 9-(5-substitutedimidazolyl)carbazoles
4.Feda'a Al-Masri
Synthesis and Characterization   of Some Pyrazolo[3,4-b]pyrazinones

2015-Present: Professor

2008-2015: Associate Professor

2012-2014:  Head of Chemistry Department, Hashemite    University/ Jordan
  
2009-2010: Vice Dean, Faculty of Science, Hashemite    University/ Jordan 

2008-2009: Head of Chemistry Department, Hashemite    University/ Jordan 
          
2001– 2008: Assistant Professor

2000 – 2001: Lecture

 1. General Chemistry: 103101 & 103102
 2. Coordinator for General Chemistry  Labs: 103103 & 103104
 3.Undergraduate Organic Chemistry: 103231; 103232; 103236 & 103432.
 4. Undergraduate Special Topics: 103495.
 5. Undergraduate Organic Chemistry Labs: 103235 & 103335.
 6.Graduate Courses 103732(Heterocyclic Chemistry)& 103793 (Research Methods)

2015-Present: Professor- Hashemite University/ Jordan

2014-2015: Associate Professor-King Khalid University/ Saudi
           Arabia

2010-2011: Associate Professor-King Khalid University/ Saudi
            Aeabia
                 
2001– 2008: Assistant Professor-Hashemite University/ Jordan

2000 – 2001: Lecture-Hashemite University/ Jordan

1996 – 1998: Lecture-Hashemite University/ Jordan

1991 – 1996: Teaching Assistant, Yarmouk University/ Jordan Jordan
1989 – 1991: Teaching Assistant, King Saud University/ Saudia     Arabia               
        
1985– 1989: Secondary School Teacher/ Jordan.

 • Member of the Jordanian Chemical Society, Since 1982. 
 • Member of the Jordan Society for Scientific Research-   Jordan, Since 2000.

 1. 9 th   Ibn Sina International Conference of Pure and Applied Heterocyclic Chemistry, (11-14/12/2004), Poster (Synthetic & Chararacterization of some New Pentadienoic Acid Derivatives).(Egypt)
2. 10th Ibn Sina International Conference of Pure and Applied Heterocyclic Chemistry, (17-20) /2/2007, Oral presentation (Synthesis of 5-Substituted 1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazines) (Egypt)
3. Petra International Chemistry Conference (PICC) and Tran smediterranean Colloquium on Heterocyclic Chemistry (TRAMECH-5), Petra, Jordan, (25-28/6/2007), Oral presentation (Synthesis of 8-substituted-12-methyl-12H-imidazo-[4`,5`:2,3][1,4]diazepino[6,7,1-jk]carbazoles) (Jordan)

KAYED ABED ALFATTAH ZAPEN ABUSAFIEH

KAYED ABED ALFATTAH ZAPEN ABUSAFIEH

Welcome to the Hashemite University faculty staff website.