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LUBNA HAMID TAWFIQ TAHTAMOUNI
Faculty of Science
LUBNA HAMID TAWFIQ TAHTAMOUNI
Faculty of Science
عربي
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Welcome to the Hashemite University faculty staff website.
Lubna Hamid Tawfiq Tahtamouni
Professor
Biological Sciences/Zoology/Developmental Biology
Developmental Biology
Faculty of Science
Department of Biology and Biotechnology
lubnatahtamuni@hu.edu.jo
http://staff.hu.edu.jo/aaa
ORCID ID :
Office No. :
ح 110/5031
EXT :
5031
C.V. Document file as PDF:
Ph.D.
Colorado State University
The United States of America,2005
Master
University of Jordan
Jordan,2000
Bachelor
University of Jordan
Jordan,1997
Cancer arises from changes in basic cell functions. My lab studies cellular alternations leading to cancer for a better understanding of its initiation and development. This information can help in creating and improving cancer treatments. The lab different projects focus on: Cell migration, adhesion and metastasis; Mitochondrial function and apoptosis; Cytoskeleton and related proteins; Cell cycle and Anti-tumor drugs screening. My lab collaborates with other researches interested in basic, translational and clinical sciences. The same biological concepts are applied in the lab projects studying male infertility.
Tahtamouni L, Nawasreh M, Al-Mazaydeh Z, Al-Khateeb R, Abdellatif R, Bawadi R, Bamburg J, Yasin S. Cephalostatin 1 Analogues Activate Endoplasmic Reticulum Stress Apoptotic Signaling Pathway. (2017). European Journal of Pharmacology (in press). Khadra MM, Freij MA, Al-Mazaydeh Z, Saleh S, Kilani R, Tahtamouni LH. (2017). Factors Influencing Successful Pregnancy Outcomes in IVF Cycles among Jordanian Infertile Couples. Clinical and Experimental Obstetrics & Gynecology (in press). Nawasreh MM, Tahtamouni LH. (2017). The Effect of Orchis anatolica Leaves on Reproductive System-An in Vivo Study. International Journal of Pharma Medicine and Biological Sciences 6 (2): 63-66. Mazen A Freij, Maysa M Khadra, Husam A Abu Farsakh, Hanan H Saleh, Altaf A Ijmail, Bushra O Rahal, Manar H Waldali, Lubna H. Tahtamouni. (2017). Type Specific Prevalence of Human Papillomavirus among Women with Abnormal Cytology in Jordan. European Journal of Gynaecological Oncology (in press). Mazen A Freij, Maysa M Khadra, Husam A Abu Farsakh, Hanan H Saleh, Altaf A Ijmail, Bushra O Rahal, Manar H Waldali, Nisreen S. Najeeb, Lubna H. Tahtamouni. (2017). Low Rate of Cervical Cancer among Women with Rising Incidence of Cervical Cytological Abnormalities. The Unlearnt Lesson. European Journal of Gynaecological Oncology (in press). Tahtamouni LH, Abdellatif RN, Al-Khateeb RA, Al-Mazaydeh ZA, Yasin SR, Al-Gharabli SI, Elkarmi AZ. (2017). Taraxacum officinale Root Aqueous Extract Impairs the Expression of Spermatogonial Stem Cell Markers in Adult Rat. Tropical Journal of Pharmaceutical Research 16 (1): 1319-1326. Yasin S, Tahtamouni LH, Al-Khateeb R, Abdellatif R, Al-Mazaydeh Z, Al-Emerieen A,Al-Khateeb H, Al-Hadidi A-H. (2016). Screening for CYP2C19 Gene Variants in a Healthy Jordanian Population. Tropical Journal of Pharmaceutical Research 15(12):2745-2750. Abu Safieh KA, Tabba HD, AlMasri HA, Bawadi RM, Boudjelal FM, Tahtamouni LH. (2016). Novel Palladium(II) and Platinum(II) Complexes with a Fluoro Piperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer Activity in vitro. Journal of Chemistry 2016; doi:10.1155/2016/7508724. Al-Noaimi M, Abu-Surrah A, Tahtamouni LH. (2016). Palladium (II) Complexes Incorporating Phenylazo Arylmethine Ancillary Ligands: Synthesis, Spectral and Antitumor Activity. Arabian Journal of Chemistry 9: S1503-S1509. Tahtamouni LH, Al-Khateeb R, Abdellatif R, Al-Mazaydeh Z, Yasin S, Al-Gharabli S, Elkarmi AZ. (2016). Anti-spermatogenic Activities of Taraxacum officinale Leaves Aqueous Extract. Veterinary Research Forum 7(2):89-97. Khadra MM, Freij MA, Al-Ramahi MQ, Al-Jamal AY, Thekrallah FM, Tahtamouni LH. (2016). Human Chorionic Gonadotropin Cut-off Value Determined by Receiver Operating Characteristic Curve Analysis is Useful but Not Absolute for Determining Pregnancy Outcomes. Middle East Fertility Society Journal 21(2):120-124. Mustafa EH, Mahmoud HT, Al-Hudhud MY, Abdalla MY, Ahmad IM, Yasin SR, Elkarmi AZ, Tahtamouni LH. (2015) 2-Deoxy-D-glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells. Asian Pac J Cancer Prev 16(8):3213-22. Hussein AA, Bawadi RM, Tahtamouni LH, Frangoul H, Elkarmi AZ. (2014) Feasibility of Collecting Umbilical Cord Blood in Jordan and the Effect of Maternal and Neonatal Factors of Hematopoietic Stem Cell Content. Meditterranean Journal of Hematology and Infectious Diseases 2014 Feb 18;6(1):e2014019. doi: 10.4084/MJHID.2014.019 Yasin SR, Tahtamouni LH, Najeeb NS, Issa NM, Al-Mazaydeh ZA, Alfaouri AA. (2014) Genomic Integrity of the Y Chromosome Sequence-tagged Sites in Infertile and Down Syndrome Jordanian males. Andrologia 46(7):770-776. Tahtamouni LH, Shaw AE, Hasan MH, Yasin SR, Bamburg JR. (2013) Non-overlapping Activities of ADF and Cofilin-1 During the Migration of Metastatic Breast Tumor Cells. BMC Cell Biology 2013 Oct 5;14:45. doi: 10.1186/1471-2121-14-45. Al-Zu'be L, Al-Momani T, Al-Bataineh O, Tahtamouni LH. (2013). In vitro Characterization of Calcium Salts as Delivery Vehicles for Insulin. Journal of Biomimetics, Biomaterials & Tissue Engineering 17 (2013):53-58. Tahtamouni LH. (2013) Use of Anabolic Androgenic Steroids in Jordan: Mini- Review. Jordan Journal of Biological Sciences 6(1):1-4. Tahtamouni, LH, Alqurna NM, Al-Hudhud MY, Al-Hajj HA. (2011) Dandelion (Taraxacum officinale) Decreases Male Rat Fertility in vivo. Journal of Ethnopharmacology 135(1):102-9 Kadir S, Astin J, Tahtamouni LH, Martin P, Nobes C. (2011). Microtubule Remodeling is Required for the Front-Rear Polarity Switch During Contact Inhibition of Locomotion. Journal of Cell Science 124(Pt 15):2642-2653. Tahtamouni LH, Bamburg JR. (2011) Redundant and Non-Redundant Functions of ADF and Cofilin in Metastasis. Jordan Journal of Biological Sciences 4(1):1-12 Tahtamouni LH, Mustafa NH, Hassan IM, Ahmad IM, Abdalla MY. (2010) Nandrolone Decanoate Administration to Male Rats Induces Oxidative Stress, Seminiferous Tubules Abnormalities, and Sperm DNA Fragmentation. Jordan Journal of Biological Sciences 3(4):165-174. Ahmad IM, Mustafa IH, Mustafa NH, Tahtamouni LH, Abdalla MY. (2010) 2-Deoxy-D-Glucose Enhances the Susceptibility of Breast Cancer Cells to Doxorubicin-induced Metabolic Oxidative Damage. Central European Journal of Biology 5(6):739-748. Abdalla MY, Hassan IM, Mustafa NH, Tahtamouni LH, Ahmad IM. (2010) Total Body Glutathione Depletion Induces Oxidative Stress and Disrupts the Immune Function in Mice. Toxicological & Environmental Chemistry, 1-14 (iFirst). Tahtamouni LH, Wahdan RA, Elkarmi AZ. (2009) Sperm Chromatin Abnormalities Evaluated by Acridine Orange Staining Effect Developmental Rate and Embryo Quality. Jordan Journal of Biological Sciences 2(4):171-176. Tahtamouni LH, Mustafa NH, Alfaouri AA, Hassan IM, Abdalla MY, Yasin SR. (2008) Prevalence and Risk Factors for Anabolic-Androgenic Steroid Abuse among Jordanian Collegiate Students and Athletes. European Journal of Public Health 18(6):661–665. Kile BT, Panopoulos AD, Stirzaker RA, Hacking DF, Tahtamouni LH, Willson TA, Mielke LA, Henley KJ, Zhang J-G, Wicks IP, Stevenson WS, Nurden P, Watowich SS, Justice MJ. (2007) Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood 110 (7): 2371-2380. Al-Qaisi KH, Elkarmi A, Qnais E, Tahtamouni L, Abu-Samak M. (2006) Allometry of postnatal rat brain development prenatally exposed to aspirin. Pakistan Journal of Biological Sciences 9(7):1212-1218. Kamel A, Qnais E, Khoury F, Tahtamouni LH, Massadeh M, Al-Matubsi H, Ghalyun YA. (2006) Reptilian skeletal muscle: physiological and fine structure properties of musculus iliofibularis of the lizard Chamaeleo chamaeleo recticrista. Proc Fourth Internat Conf Biol Sci 201-205. Tahtamouni LH. (2005) The role of mDia1 during the initiation of polarization and migration of chick embryo cardiac fibroblasts. PhD, Colorado State University, 2005 DAI-B 66/08, p. 4094, Feb 2006. Proquest Dissertation and Theses. T Tahtamouni LH, Al- Hajj HA, Bata MS. (2002) Evaluation of etiological factors among 702 Jordanian infertile couples. Middle East Fertility Society Journal 7 (3): 73-81.
* 2014-2016- Elham Alzyoud, Biological Activity and Apoptotic Signaling Pathway for Cephalostatin 1 Analogues, Department of Biology, The Hashemite University. * 2013-2015- Reema Al-Khateeb, The effect of flowers and leaves extract of Taraxacum officinale on spermatogonial stem cells, Department of Biology, The Hashemite University. * 2013-2015- Reem Abd Al-Lateef, Gene regulation of spermatogonial stem cell specific markers under the effect of Taraxacum officinale stem and root, Department of Biology, The Hashemite University. * 2012-2014- Ala’a Al-Emerieen, CYP2C19*2 and *3 genotypes determined by polymerase chain reaction/restriction fragment length (PCR/RFLP) assay, Department of Biology, The Hashemite University. * 2009-2011- Maram Husni, The role of ADF/coflin signaling pathway during the metastasis of MTLn3 breast adenocarcinoma cells, Department of Biology, The Hashemite University. * 2009-2011- Huda Mahmoud, Oxidative Stress Mediated by Glutathione Depletion Regulates Breast Cancer cells Metastasis and Adhesion, Department of Biology, The Hashemite University. * 2009-2012- Randa Bawadi, The Effect of Maternal Age, Number of Previous Births and Gender of the Fetus on the Quality of Umbilical Cord Blood in the Jordanian Population, Department of Biology, The Hashemite University. * 2009-2011- Ibtihal Mustafa- The Effect of Glucose Analog [2-Deoxy-D-Glucose (2DG)] in Combination with Glutathione Depletion on Doxorubicin-Induced Oxidative Damage in Breast Cancer Cells, Department of Biology, The Hashemite University. * 2007-2010- Noor AlQurna, The Effects of the Aqueous Extract of Taraxacum officinale on Male Rats Fertility, Department of Biology, University of Jordan. * 2006-2008- Noor Mustafa, The effects of supraphysiological dosing of anabolic-androgenic steroids on rat sperm chromatin abnormalities, Department of Biology, The Hashemite University. * 2005-2009- Rania Wahdan, Relationship between the outcomes of Assisted reproductive technique and Seminal Fluid Analysis and Sperm DNA Fragmentation as measured by The Acridine Orange Staining, Department of Biology, The Hashemite University.
September 2017-Present: Chair, Dep. of Biology and Biotechnology, The Hashemite University, Zarqa, Jordan. August 2015- July 2017: Assistant Editor, Jordan Journal of Biological Sciences, The Hashemite University, Zarqa, Jordan. August 2011-Present: Associate Professor, Dep. of Biology and Biotechnology, The Hashemite University, Zarqa, Jordan. September 2013- September 2014: Sabbatical leave/Visiting Professor, Dep. of Pharmaceutical Engineering, German Jordan University, Amman, Jordan. March 2013- present: Member of the Editorial Board of HSOA Journal of Cancer Biology and Treatment. September 2012-present: Institute Review Board (IRB) member, The Hashemite University, Zarqa, Jordan. September 2011- August 2013: Chair, Dep. of Biology and Biotechnology, The Hashemite University, Zarqa, Jordan. March 2011- present: Member of the Editorial Advisory Board of TANG (International Journal of Humanitas Medicine). September 2010-August 2011: Managing the Office of Externally Funded Projects, Deanship of Scientific Research and Graduate Studies, The Hashemite University, Zarqa, Jordan. September 2005-August 2011: Assistant Professor, Dep. of Biology and Biotechnology, The Hashemite University, Zarqa, Jordan. August 2002-May 2005: Student Teaching Assistant, Dep. of Biology, Colorado State University, Colorado, USA. February 2000-June 2001: Teaching Assistant, Dep. of Biology, The Hashemite University, Zarqa, Jordan. September 1996-December 1999: Student Teaching Assistant, Dep. of Biology, The University of Jordan, Amman, Jordan.
* Since Sep. 2005- Developmental Biology, Applied Developmental Biology, Microtechniques, General Biology, Recombinant DNA Technology, Tissue Culture, Gene Expression, Electron Microscopy, Cancer Biology, Special topics in Advanced Cell Biology; The Hashemite University. * Lectured and supervised lab activities for the following courses: - 1997 to 2000- Embryology and General Practical Biology; The University of Jordan. - 2000 to 2001- Embryology, Ecology, Animal Physiology, Histology, Electron Microcopy, Hematology, Endocrinology, and General Practical Biology; The Hashemite University. - 2002 to 2005- Cell Biology; Colorado State University: 3 years.
Lectured and supervised lab activities for the following courses: -Embryology and General Practical Biology; The University of Jordan: 3 years -Embryology, Ecology, Animal Physiology, Histology, Electron Microcopy, Hematology, Endocrinology, and General Practical Biology; The Hashemite University: 18 months -Cell Biology; Colorado State University: 3 years. -Developmental Biology, Applied Developmental Biology, Microtechniques, General Biology; The Hashemite University, Since Sep. 2005. General Biology "1", Applied Developmental Biology, Developmental Biology, MicrotechniquesPractical General Biology "1"
* American Society for Cell Biology/USA: Member since 2004 * Jordan Society for Scientific Research (JSSR): Member since 2005 * Organization for Women in Science for the Developing World (OWSD): Member since 2009 * Arab Science and Technology Foundation (ASTF), Women Network in Science and Technology: Member since 2011 * The Jordanian Society for Fertility and Genetics: Member since 2015
Visiting Scientist (June-Aug 2017): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2016): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2012): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2011): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2010): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2008): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2007): Dep. of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado, USA. Visiting Scientist (June-Aug 2006): Cancer and Hematology, and Autoimmunity and Transplantation Divisions, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
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