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MA'MON MOHAMMAD ALI MAHMOUD HATMAL
Faculty of Applied Health Sciences
MA'MON MOHAMMAD ALI MAHMOUD HATMAL
Faculty of Applied Health Sciences
عربي
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Welcome to the Hashemite University faculty staff website.
Mamon Mohammad Ali Mahmoud Hatmal
Professor
Biochemistry and Molecular Biology
Biochemistry and Molecular Biology
Faculty of Applied Health Sciences
Department of Medical Laboratory Sciences
Mamon@hu.edu.jo
http://staff.hu.edu.jo/mamonhatmal
ORCID ID :
317458985
Office No. :
5567
EXT :
5567 , 4585
C.V. Document file as PDF:
Ph.D.
University of southern California
The United States of America,2011
Master
University of southern California
,
Bachelor
Hashemite University
Jordan,2004
• Bioinformatics, in particular computer-aided molecular design and discovery towards new bioactive compounds, computational prediction of 3D structures of biological macromolecules, and statistical analysis of biomedical data (which include writing self codes with FORTRAN, C++, PyMOL, VMD, MATLAB, PHP, Kotlin, Python and others). • Exploring the anti-cancer properties of natural products of animal or herbal origins. • Determining genetic factors associated with different diseases including cancer, diabetes, and immune system conditions.
• Hatmal MM, Abuyman O, Taha M. Docking-Generated Multiple Ligand Poses for Bootstrapping Bioactivity Classifying Machine Learning: Repurposing Covalent Inhibitors for COVID-19-Related TMPRSS2 as Case Study. Comput Struct Biotechnol J. 2021 Aug 19. • Hatmal MM, Alshaer W, Mahmoud IS, Al-Hatamleh MAI, Al-Ameer HJ, Abuyaman O, Zihlif M, Mohamud R, Darras M, Al Shhab M, Abu-Raideh R, Ismail H, Al-Hamadi A, Abdelhay A. Investigating the association of CD36 gene polymorphisms (rs1761667 and rs1527483) with T2DM and dyslipidemia: Statistical analysis, machine learning based prediction, and meta-analysis. PLoS One. 2021 Oct 14;16(10):e0257857. • Ahmad S, Hatmal MM, Lambuk L, Al-Hatamleh MAI, Alshaer W, Mohamud R. The role of TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy. Life Sci. 2021 Dec 1;286:120063. • Mousa L, Hatmal MM, Taha M. Exploiting Activity Cliffs and Machine Learning for Building Pharmacophore Models and Comparison with other Pharmacophore Generation Methods: Sphingosine Kinase 1 as Case Study. Journal of Computer-Aided Molecular Design (In press). • IS Mahmoud, MM Hatmal, D Abuarqoub, E Esawi, H Zalloum, S Wehaibi 1,4-Napthoquinone Is a Potent Inhibitor of IRAK1 Kinases and the Production of Inflammatory Cytokines in THP-1 Differentiated Macrophages. ACS Omega, 2021. • Lafi Z, Alshaer W, Hatmal MM, Zihlif M, Alqudah DA, Nsairat H, Azzam H, Aburjaih T, Bustanjih Y, Awidi A. Aptamer-functionalized pH-sensitive liposomes for selective delivery of echinomycin into cancer cells. RSC Advances, 47; 2021. • Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Hatmal M, Alhaj-Qasem DM, Olaimat TM, Mohamud R. Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects. Vaccines (Basel), MDPI (Switzerland), 26;9(6):556, 2021. 4 • Alshaer W, Zureigat H, Al Karaki A, Al-Kadash A, Gharaibeh L, Hatmal MM, Aljabali AAA, Awidi A. siRNA: Mechanism of action, challenges, and therapeutic approaches. European Journal of Pharmacology, Elsevier (Netherlands), 905:174178, 2021. • Khamees M, Jarrar Y, Al-Qirim T, Mahmoud IS, Hatmal MM, Alshaer W, Lee SJ. No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients. International Journal of Clinical Practice, John Wiley & Sons (United States), 75(5):e14036, 2021. • Al-Hatamleh MAI, Hatmal MM, Alshaer W, Rahman ENSEA, Mohd-Zahid MH, Alhaj-Qasem DM, Yean CY, Alias IZ, Jaafar J, Ferji K, Six JL, Uskokovi? V, Yabu H, Mohamud R. COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes. European Journal of Pharmacology. Elsevier (Netherlands), 896:173930, 2021. • Hatmal MM, Alshaer W, Al-Hatamleh MAI, Hatmal M, Smadi O, Taha MO, Oweida AJ, Boer JC, Mohamud R, Plebanski M. Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2. Cells, MDPI (Switzerland), 9(12):2638, 2020. • Al-Hatamleh MAI, Hatmal MM, Sattar K, Ahmad S, Mustafa MZ, Bittencourt MC, Mohamud R. Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future Directions. Molecules, MDPI (Switzerland), 25(21):0, 2020. • Hatmal MM, Abderrahman SM, Nimer W, Al-Eisawi Z, Al-Ameer HJ, Al-Hatamleh MAI, Mohamud R, Alshaer W. Artificial Neural Networks Model for Predicting Type 2 Diabetes Mellitus Based on VDR Gene FokI Polymorphism, Lipid Profile and Demographic Data. Biology (Basel), MDPI (Switzerland), 9(8):222, 2020. • Azab B, Dardas Z, Rabab'h O, Srour L, Telfah H, Hatmal MM, Mustafa L, Rashdan L, Altamimi E. Enteric anendocrinosis attributable to a novel Neurogenin-3 variant. European Journal of Medical Genetics, Elsevier (Netherlands), 63(9):103981, 2020. • Abu-Ameerh M, Mohammad H, Dardas Z, Barham R, Ali D, Bijawi M, Tawalbeh M, Amr S, Hatmal MM, Al-Bdour M, Awidi A, Azab B. Extending the spectrum of CLRN1- and ABCA4-associated inherited retinal dystrophies caused by novel and recurrent variants using exome sequencing. Molecular Genetics & Genomic Medicine, Wiley Online Library (United States), 8(3):e1123, 2020. • Hatmal MM, Issa NN, Alshaer W, Al-Ameer HJ, Abuyaman O, Tayyem R, Hijjawi NS. Association of Breastfeeding Duration with Susceptibility to Allergy, Influenza, and Methylation Status of TLR1 Gene. Medicina (Kaunas), MDPI (Switzerland), 55(9):535, 2019. • Alshaer W, Alqudah DA, Wehaibi S, Abuarqoub D, Zihlif M, Hatmal MM, Awidi A. Downregulation of STAT3, ?-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin. International Journal of Molecular Sciences, MDPI (Switzerland), 20(15):3696, 2019. • Tuffaha GO, Hatmal MM, Taha MO. Discovery of new JNK3 inhibitory chemotypes via QSAR-Guided selection of docking-based pharmacophores and comparison with other 5 structure-based pharmacophore modeling methods. Journal of Molecular Graphics and Modelling, Elsevier (Netherlands), 91:30-51, 2019. • Mahmoud IS, Homsi A, Al-Ameer HJ, Alzyoud J, Darras M, Shhab MA, Zihlif M, Hatmal MM, Alshaer W. Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes. World Journal of Diabetes, the Baishideng Publishing Group (United States). 10(3):181-188, 2019. • Hatmal MM, Taha MO. Combining Stochastic Deformation/Relaxation and Intermolecular Contacts Analysis for Extracting Pharmacophores from Ligand-Receptor Complexes. Journal of Chemical Information and Modeling, American Chemical Society (United States). 58(4):879-893, 2018. • Hatmal MM, Nuirat A, Zihlif MA, Taha MO. Exploring the influence of culture conditions on kefir's anticancer properties, Journal of Dairy Science, Elsevier (Netherlands), 101(5):3771-3777, 2018. • Hijjawi N, Yang R, Hatmal MM, Yassin Y, Mharib T, Mukbel R, Mahmoud SA, Al-Shudifat AE, Ryan U. Comparison of ELISA, nested PCR and sequencing and a novel qPCR for detection of Giardia isolates from Jordan. Experimental Parasitology, Elsevier (Netherlands), 185:23-28, 2018. • Alshaer W, Ababneh N, Hatmal MM, Izmirli H, Choukeife M, Shraim A, Sharar N, Abu-Shiekah A, Odeh F, Al Bawab A, Awidi A, Ismail S. Selection and targeting of EpCAM protein by ssDNAaptamer. PLoS One, Public Library of Science (United States), 12(12):e0189558, 2017. • Hatmal MM, Taha MO. Simulated annealing molecular dynamics and ligand-receptor contacts analysis for pharmacophore modeling. Future Medicinal Chemistry, Future Medicine Ltd (UK), 9(11):1141-1159, 2017. • Hatmal MM, Abderrahman S, Alsholi D. Determining the anti-tumor effects of different extracting methods of arum palaestinum on different cancer cell lines by in vitro assay. Pharmacologyonline, SILAE (Italy), 1,28:45, 2017. • Hatmal MM, Jaber S, Taha MO. Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies. Journal of Computer-Aided Molecular Design, Springer (Germany), 30(12):1149-1163, 2016. • Mukbel RM, Khasharmeh RH, Hijjawi NS, Khalifeh MS, Hatmal MM, McDowell MA. Human immune response to salivary proteins of wild-caught Phlebotomuspapatasi. Parasitology Research, Springer (Germany), 115(9):3345-55, 2016. • Al-Zboon E, Hatmal MM. Attitudes of dentists toward persons with intellectual disabilities in Jordanian hospitals. Special Care in Dentistry, Wiley Online Library (United States). 36(1):25-31, 2016. • Abderrahman, SM; Abdallah S, Hatmal, MM. Genotoxic and cytotoxic effects of alkaloids extracted from rubiacordifolia roots on mice bone marrow cells. Pharmacologyonline, SILAE (Italy), 1,133:140, 2016. • Taha MO, Habash M, Hatmal MM, Abdelazeem AH, Qandil A. Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators. Journal of Molecular Graphics and Modelling, Elsevier (Netherlands) ,56:91-102, 2015. 6 • Li Y, Hatmal MM, Langen R, Haworth IS. Idealized models of protofilaments of human islet amyloid polypeptide. Journal of Chemical Information and Modeling, American Chemical Society (United States), 52(11):2983-91, 2012. • Popova AM#, Hatmal MM#, Frushicheva MP, Price EA, Qin PZ, Haworth IS. Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations. The Journal of Physical Chemistry B, American Chemical Society (United States), 116(22):6387-96, 2012, (#: Joint first author). • Zhang X, Tung CS, Sowa GZ, Hatmal MM, Haworth IS, Qin PZ. Global structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling. Journal of the American Chemical Society, American Chemical Society (United States), 134(5):2644-52, 2012. • Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth IS. Computer modeling of nitroxide spin labels on proteins. Biopolymers, John Wiley & Sons (United States), 97(1):35-44, 2012. • Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth IS, Lieber MR. Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology (United States),284(11):7157-64, 2009. • Konecny GE, Santos L, Winterhoff B, Hatmal MM, Keeney GL, Mariani A, Jones M, Neuper C, Thomas B, Muderspach L, Riehle D, Wang HJ, Dowdy S, Podratz KC, Press MF. HER2 gene amplification and EGFR expression in a large cohort of surgically staged patients with nonendometrioid (type II) endometrial cancer. British Journal of Cancer, Nature Research (UK), 100(1):89-95, 2009.
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