MUSA IBRAHIM MUSA ELBARGHOUTHI

Musa Ibrahim Musa El-Barghouthi	Professor
Physical Chemistry	Physical Chemistry
Faculty of Science	Department of Chemistry
musab@hu.edu.jo	http://staff.hu.edu.jo/elbarghouthi
ORCID ID : 31961796
Office No. : 4518	EXT : 4518

C.V. Document file as PDF:

Ph.D.	Jordan University	Jordan,2000
Master	Jordan University	Jordan,1995
Bachelor	Yarmouk University	Jordan,1992

 1- Studying the extent and assessing the modes of solubility enhancement exerted by aqueous cyclodextrins on some water insoluble compounds of pharmaceutical interest
2- Molecular dynamics simulation and free energy perturbation calculations of cyclodextrin inclusion complexes.
3- Protein Dynamics 
4- Removal of organic and inorganic pollutants by natural and synthetic adsorbents.

1.	Malhis L. D., Bodoor K., Assaf K. I., Al-Sakhen N. , El-Barghouthi M. I., Molecular dynamics simulation of a cucurbituril based molecular switch triggered by pH changes, Computational and Theoretical Chemistry, 1066, 104-112 (2015).
2.	El-Barghouthi M. I., Abdel-Halim H. M., Haj-Ibrahima F. J. Bodoor K., Assaf K., Molecular Dynamics of Nor-Seco-Cucurbit[10]uril Complexes, Journal of Inclusion Phenomena and Macrocyclic Chemistry (2015).
3.	El-Barghouthi M. I., Abdel-Halim H. M., Haj-Ibrahima F. J. & Assaf K. Molecular dynamics simulation study of the structural features and inclusion capacities of cucurbit[6]uril derivatives in aqueous solutions, supramolecular Chemistry, 27, 80-89 (2015).
4.	Al-Hourani B, El-Barghouthi M. I., Mcdonald R, Al-Awaida W, Wuest F. Docking studies and the crystal structure of two tetrazole derivatives: 5-(4-chlorophenyl)-1-{4-(methylsulfonyl)phenyl}-1H-tetrazole and 4-{5-(4-methoxyphenyl)-1H-tetrazol-1-yl}benzenesulfonamide, Journal of Molecular Structure 1101, 21-27 (2015)
5.	Ibrahim M., Ali B.F., El-Barghouthi M. I., Zaghal M. & Frey W. Crystal, Molecular Structure and DFT Study of 2,6,7-Trimethyl-3-p- tolylquinoxaline and 2-(4- Methoxyphenyl)-3,6,7- trimethylquinoxaline, Journal of Chemical Crystallography, 45, 319-329 (2015)
6.	Abu-Safieh K. A, Khanfar M. A., El-Barghouthi M. I., Ali, B. F., Molecular Structure and Density Functional Theory Calculations of 3-(3-Nitrothien-2-yl)indole: Structural and Vibrational Analysis, Journal of Chemical Crystallography, 44, 330-336 (2014)
7.	Wong DB, Sokolowsky KP, El-Barghouthi M. I., Fenn EE, Giammanco CH, Sturlaugson AL, Fayer MD., Water Dynamics in Water/DMSO Binary Mixtures, J Phys Chem B. 116 (18), 5479–5490 (2012).
8.	Al-Noaimi M., El-Barghouthi M.I., Haddad S. F., Rawashdeh¬ A. M., Abdel-Rahman O.S, X-Ray Structure and DFT Study of neutral Mixed Phosphine Azoimine complexes of Ruthenium, Polyhedron, 30, 1884–1890 (2011). 
9.	El-Barghouthi M. I., Assaf K. I., Rawashdeh A. M., Molecular Dynamics of Methyl Viologen-Cucurbit[n]uril Complexes in Aqueous Solution, J. of Chemical Theory and Computations, 6, 984-992 (2010)
10.	El-Barghouthi M. I., Saleh A. I., Ghandour A., Ghanem R., Zacharias M., Examining the potency of suggested inhibitors for the phosphatase activity of the human soluble epoxide hydrolase by molecular dynamics simulations, J. of Molecular Structure (Theochem), 944, 97-104 (2010).
11.	Al Omari M. M., El-Barghouthi M.I., Zughul M.B.,DaviesJ.E.D, BadwanA. A., The role of drug hydrophobicity in ?-cyclodextrin complexes, J. Molecular Liquid, 155, 103-108 (2010).
12.	El-Sheikh A.H., Al-Quse R.W., El-Barghouthi M.I. and Al-Masri F.S. Derivatization of 2-chlorophenol with 4-amino-anti-pyrine: A novel method for improving the selectivity of molecularly imprinted solid phase extraction of 2-chlorophenol from water, Talanta, 83, 667–673 (2010). 
13.	Rawashdeh A. M., El-Barghouthi M. I., Assaf K. I., Al-Gharabli S. I.,complexation of n-methyl-4-(p-methyl benzoyl)- pyridinium methyl cation and its neutral analogue by cucurbit[7]uril and ?-cyclodextrin. a computational study, Journal of Inclusion Phenomena & Macrocyclic Chemistry, 64, 357-365 (2009).
14.	Al omari M. M., Daraghmeh N. D., El-Barghouthi M. I., M. B. Zughul, Chowdhry B. Z., Leharne S. A. and Badwan A. A., Novel inclusion complex of ibuprofen tromethamine with cyclodextrin, Journal of Pharmaceutical and Biomedical Analysis, 50, 449-458 (2009)
15.	Al Omari M. M., El-Barghouthi M. I., Zughul M. B., Davies J. E. and Badwan A. A., Dipyridamole/?-cyclodextrin complex: buffer species effect on stability constants, thermodynamics, and guest-host interactions probed by 1H-NMR and molecular modeling studies, Journal of Inclusion Phenomena & Macrocyclic Chemistry, 64, 305-315 (2009).
16.	Eftaiha E. F., El-Barghouthi M. I., Rashid I. S., Al-Remawi M. M., Saleh A. I., and Badwan A. A., Compressibility and compactibility studies of chitosan, xanthan gum and their mixtures, Journal of Material Science, 44, 1054-1062 (2009)
17.	El-Barghouthi M. I., Jaime C., Akielah R. E., Al-Sakhen N. A., Masoud N. A., Issa A. A., Badwan A. A. and Zughul M. B.,. Free energy perturbation and MM/PBSA studies on inclusion complexes of some structurally related compounds with ?-cyclodextrin, Supramolecular Chemistry, 21, 603-610.
18.	Abu-Surrah A. S., Al-Degs Y. S., El-Barghouthi M. I., Preparation of a Highly Selective Adsorbent for Toxic SudanIV Dye Using Imprinted Polymer Technology, Research Journal of Chemistry and Environment, 15, 183-187 (2010)
19.	El-Barghouthi M. I., Jaime C., Al-Sakhen N. A., Issa A. A., Abdoh A. A., Al Omari M. M., Badwan a. A. and Zughul.M. B., Molecular dynamics simulations and mm-pbsa calculations of the cyclodextrin inclusion complexes with 1-alkanols, para substituted phenols and substituted imidazoles. Journal of Molecular Structure (THEOCHEM), 853, 45-52 (2008).
20.	Al Omari M. M., El-Barghouthi M. I., Zughul M. B., Davies J. D. E. and Badwan A.   A., Comparative study of the inclusion complexation of pizotifen and ketotifen with native and hydroxypropyl ?-cyclodextrins, Journal of Solution Chemistry, 37, 249-264 (2008).
21.	El-Barghouthi M. I., Rashid I., Eftaiha A., Al-Remawi M., Badwan A., A novel superdisintegrating agent made from physically modified chitosan with silicon dioxide, Drug Development & Industrial Pharmacy, 34, 3737-383 (2008).
22.	Al-Noaimi M. Z., El-Barghouthi M. I., El-khateeb M., Subhi O., G?rls H. Crutchley R. J., Synthesis, characterization of ruthenium(ii) azoimine-diphosphine mixed-ligand complexes, Polyhedron, 27 2698-2704 (2008).
23.	Abdoh A. A., El-Barghouthi M. I., M. M. Omari, Zughul M.B. and Badwan A. A. Inclusion complexation of ketorolac with ?-, ?-, ?- and 2-hydroxypropyl-?-cyclodextrins, phase solubility, proton nmr and molecular modeling studies, proceedings of  the 14th International Cyclodextrin Symposium, Kyoto, Japan, May 8-11, 377-380 (2008).
24.	Al-Degs Y. S, El-Barghouthi M. I., El-Sheikh A. H. and Walker G., Effect of solution pH, ionic strength, and temperature on adsorption behavior of reactive dyes on activated carbon, Dyes and pigments, 77, 16-23 (2008).
25.	El-Barghouthi M. I., El-Sheikh A. H., Al-Degs Y. S.,  Walker G. M., Adsorption behavior of anionic reactive dyes on h-type activated carbon: competitive adsorption and desorption studies, Separation Science and Technology, 42,  2195-2220 (2007)
26.	Al-Noaimi M. Z., Saadeh H., Haddad S. F., El-Barghouthi M. I., El-khateeb M., Crutchley R. J., Syntheses, crystallography and spectroelectrochemical studies of ruthenium azomethine complexes, Polyhedron, 26, 3675-3685 (2007).
27.	Omar L., El-Barghouthi M. I., Masoud N., Abdoh A. A., Al Omari M., Zughul M. B. and Badwan A. A., Inclusion complexation of loratadine with natural and modified cyclodextrins: phase solubility and thermodynamic studies, Journal of Solution Chemistry, 36, 605-616 (2007).
28.	El-Barghouthi M. I., Schenk M.,  Zughul M. B., Badwan A. A. and. van Gunsteren W. F., Comparison of estimates of free energy for binding of mono- and di-substituted benzenes with ?-cyclodextrin obtained by single-step perturbation and thermodynamic integration” Journal of  Inclusion Phenomena & Macrocyclic Chemistry, 57, 375-377 (2007).
29.	Abdoh, A. A., El-Barghouthi M. I., Zughul M. B., and Badwan A. A., Changes in conformational structure, microscopic and macroscopic pkas of meloxicam on complexation with natural and modified cyclodextrins, Pharmazie, 62, 55-59 (2007).
30.	El-Barghouthi M. I., Abu-safieh K. A., Ayoub M. T., and Mubarak M. S., Ring substitutional requirement for biological activity of 5-aryl-3-alkoxy-(2e,4e)-2,4-pentadienoic acids as new growth regulators. [part-i] theoretical treatment” Saudi Journal of Chemistry, 11, 341-350 (2007).
31.	El-Barghouthi M. I., Masoud N., Al-Kafawein J. and Abdoh A. A., Inclusion complexation of itraconazole with ?- and 2-hydroxypropyl-?-cyclodextrins in aqueous solutions, Russian Journal of Physical Chemistry, 80, 1050-1055 (2006).
32.	Alani K., El-Barghouthi M. I., Al-Buzzour M., Effect of polymeric additives on thermal degradation of para subsituted polystyrenes in solution,  polymer degradation and stability, 91, 3252-3258 (2006).
33.	Al-Degs Y., El-Barghouthi M. I., Issa A. A., Khraisheh M., Walker G., Adsorption of zn(ii), pb(ii), and co(ii) using natural sorbents: equilibrium and kinetic studies” Water research, 40, 2645-2658 (2006).
34.	El-Barghouthi, M. I., Masoud N., Al-Kafawein J, Zughul M. B. and Badwan A. A., Host-guest interactions of risperidone with natural and modified cyclodextrin: phase solubility, thermodynamics and molecular modeling studies, Journal of Inclusion Phenomena & Macrocyclic Chemistry 53, 15-22 (2005).
35.	El-Barghouthi M. I., Al-Sou’od K. A., Zughul M. B. and Badwan A. A., Trends in the complexation of organic molecules bearing two peripheral benzene rings   with aqueous ?-cyclodextrin, proceedings of  the 12th International Cyclodextrin Symposium, Montpellier, France, May 16-19, 267-270 (2004)
36.	El-Barghouthi, M. I., Masoud N., Al-Kafawein J., Zughul M. B. and Badwan A. A ., Inclusion complex thermodynamics of risperidone  with natural and modified cyclodextrins, proceedings of  the 12th International Cyclodextrin Symposium, Montpellier, France, May 16-19, 507-510 (2004)
37.	Al-Sou’od K. A., El-Barghouthi M. I., Zughul M. B. and Badwan A. A., Experimental and molecular mechanical studies of complexation of some 2H- and 3H- indole derivatives with ?-cyclodextrins, proceedings of the 12th International Cyclodextrin Symposium, Montpellier, France, May 16-19, 511-514 (2004).
38.	Al-Degs Y., El-Barghouthi M. I., Khraisheh M., Ahmad M., and Allen S., Effect of surface area, micropores, secondary micropores and mesopores volumes of activated carbons on reactive dyes adsorption from solution, Separation Science and Technology, 39, 97-111 (2004).  
39.	El-Barghouthi M. I. and Al-Degs Y. "Interactions of Some Organic Compounds with ?-, ?- and ?-Cyclodextrins. A Molecular Mechanics Study", Asian Journal of Chemistry, 16, 207-212 (2004).
40.	Al-Degs Y., El-Barghouthi M. I. and Tutunji M., Evaluation of Natural Diatomite for Heavy Metals Adsorption, Dirassat, 31, 8-15 (2004).
41.	El-Barghouthi M. I., Al-Sou'od K., Abu-Nawas H. and Abu El-Halawa R., Kinetics and Mechanism of Benzoin oxidation using  Iron(III) in the Presence of 1,10-Phenanthroline  in Acidic Medium, International Journal of Chemistry, 14, 77-84 (2004).
42.	El-Barghouthi M. I. and Al-Degs Y. S., Molecular mechanics calculations of inclusion complexes of phenol and benzoic acid with ?-cyclodextrin using mm and amber force fields” Oriental Journal Chemistry, 19, 293-300 (2003).
43.	Al-Degs Y., El-Barghouthi M. I.  and Khraisheh, M., Adsorption of Anionic Reactive Dyes from Solution by Activated Carbon: Effect of Solution pH, Asian Journal Chemistry. 15, 891-896 (2003).
44.	Al-Degs Y., Majeda A. K., Ahmad N. and El-Barghouthi, M. I., Evaluation of commercial activated carbon adsorbents for the removal of reactive dyes from solution, Dirassat, 29, 29-38 (2002)
45.	Ibrahim K. and El-Barghouthi M. I., Quantum chemical calculations of solvation  effects on the electronic absorption spectra of some ?-,?-unsaturated carbonyl  compounds"  Journal of Saudi Chemical Society, 4, 153-164 (2000).

1. Solubility enhancement of some water-insoluble drugs by complexation with polysaccharides. an experimental and theoretical study. Al-Kafawein J. 2004.
2. Thermal degradation of plasticized poly (para substituted styrene) in solid films and in solutions, Al-Buzzour M. 2005, (Co-supervisor).
3. Study on the Inclusion complexes of water insoluble drugs with natural and modified cyclodextrins, Omar L. 2006
4. Application of percolation theory on compacts utilized in pharmaceutical dosage forms, Eftatha, A. F. 2006.
5. Molecular dynamics and free energy perturbation studies on ?-cyclodextrin inclusion complexes with some organic molecules, Akeelh R. E. 2007.
6. Applying molecular dynamics simulations based on the continuum solvation models for the prediction of free energy of cyclodextrin inclusions complexes, AL-Sakhen N.  2007.
7. Molecular dynamics simulation of cucurbiturils and their inclusion complexes in aqueous solutions, Assaf K. 2009.
8. Synthesis and molecular dynamics simulation of putative inhibitors for the n terminal domain of human soluble epoxide  hydrolase, Ghandour A. 2009.
9. Synthesis, characterization and DFT calculations of Ruthenium(II) Azoimine-Diphosphine Mixed-Ligand Complexes. Subhi O. 2009 (Co-supervisor). 
10. The effect of derivatisation of phenol with 4-amino-antipyrine on their selective pre concentration from aqueous medium using molecularly imprinted polymer. Qussi R. 2009 (Co-supervisor).
11. A molecular dynamics simulation study of the structural features and inclusion capacity of cucurbit[6]uril derivatives in aqueous solutions. Ibrahim F. 2010.
12. Molecular dynamics simulation of cucurbituril based molecular switches. Dergham L., 2015

2013-present: Full Professor, Chemistry Department, The Hashemite University, Zarqa, Jordan
2008- 2013: Associate Professor, Chemistry Department, The Hashemite University, Zarqa, Jordan.
2010-2011: Sabbatical Leave, Fulbright Scholar, Stanford University, California, USA.  
2002- 2008: Assistant Professor, Chemistry Department, The Hashemite University, Zarqa, Jordan.
2000- 2002: Lecturer, Chemistry Department, The Hashemite University, Zarqa, Jordan.

General Chemistry
Thermodynamics
Quantum chemistry (graduate and undergraduate courses)
Molecular Spectroscopy
Experimental Physical Chemistry

American Chemical Society
Jordanian Chemical Society

Summer 2012: Research visit, Leiden University, Leiden, The Netherlands. 
2010-2011: Sabbatical Leave, Fulbright Scholar, Stanford University, California, USA.  
Summer 2010: Research visit, Leiden University, Leiden, The Netherlands. 
Summer 2007: Research visit, Jacobs University, Bremen, Germany. 
Summer 2006: Research visit, University of Granada, Granada, Spain. 
Summer 2005: Research visit, ETH/Zurich, Switzerland  
Summer 2004: Research visit, Autonoma University, Barcelona, Spain. 
Summer 2003: Research visit, Queen’s University, Belfast, UK.

1.	Molecular Dynamics Simulations and MM-PBSA Calculations of the Cyclodextrin Inclusion Complexes with Some Organic Compounds, El-Barghouthi M. I., Jaime C., Al-Sakhen N. A., Issa A. A., Abdoh A. A., Al Omari  M.  M., Badwan A. A. and Zughul M. B.14th International Cyclodextrin Symposium, Kyoto, Japan, May 8-11, Published Abstract, 2008.
2.	Inclusion Complexation of Ketorolac with ?-, ?-, ?- and 2-Hydroxypropyl-?-Cyclodextrins, Phase Solubility, Proton NMR and molecular Modeling Studies, Abdoh A. A., El-Barghouthi M. I., Zughul M.B. and Badwan A. A. “14th International Cyclodextrin Symposium, Kyoto, Japan, May 8-11, Published Abstract, 2008.
3.	Comparison of Estimates of Free Energy For Binding of Mono- and Di-Substituted Benzenes with ?-Cyclodextrin Obtained By Single-Step Perturbation and Thermodynamic Integration, El-Barghouthi M. I., Schenk M.,  Zughul M. B., Badwan A. A. and. van Gunsteren W. F. 13th International Cyclodextrin Symposium, Torino, Italy, May 14-17, Published Abstract, 2006.
4.	Molecular Dynamics and Free Energy Perturbation Studies on Inclusion Complexes of Some Structurally Related Compounds with ?-Cyclodextrin,  Akeelh R. E., El-Barghouthi M. I., Masoud N. A., Abdoh A. A., Al Omari M. M., Jaime C., Zughul M. B. and Badwan  A. A. 13th International Cyclodextrin Symposium, Torino, Italy, May 14-17, Published Abstract, 2006.
5.	Trends in the Complexation of Alkyl Benzoates and Alkyl p-Hydroxy Benzoates with ?-Cyclodextrin in Aqueous Solution, El-Barghouthi M. I., Zughul M. B. and Badwan A. A., 13th International Cyclodextrin Symposium, Torino, Italy, May 14-17, Published Abstract, 2006.
6.	Inclusion Complexation of Loratadine with Natural and Modified Cyclodextrins: Phase Solubility and Thermodynamic Studies, Omar L., El-Barghouthi M. I., Masoud N. A., Abdoh A. A., Al omari M. M., Zughul M. B. and Badwan A. A., 13th International Cyclodextrin Symposium, Torino, Italy, May 14-17, Published Abstract, 2006.
7.	Combining Molecular Docking Simulations and Comparative Molecular Field Analysis to Probe Drug-?-Cyclodextrin Inclusion Complexes, Zughul, M. B., Taha M. O., Al Omari M. M., El-Barghouthi M. I., Abdo A. A., Al sou'od K. and Badwan A. A. 13th International Cyclodextrin Symposium, Torino, Italy, May 14-17, Published Abstract, 2006. 
8.	Trends in the Complexation of Organic Molecules Bearing two Peripheral Benzene Rings   with Aqueous ?-Cyclodextrin, El-Barghouthi, M. I., Al-Sou’od, K. A., Zughul, M. B. and Badwan, A. A. 12th International Cyclodextrin Symposium, Montpellier, France, May 16-19, Published Abstract, 2004.
9.	Inclusion Complex Thermodynamics of Risperidone  with Natural and Modified Cyclodextrins, El-Barghouthi, M. I., Masoud, N., Al-Kafawein, J, Zughul, M. B. and Badwan, A. A “12th International Cyclodextrin Symposium, Montpellier, France, May 16-19, Published Abstract, 2004.
10.	Experimental and Molecular Mechanical Studies of Complexation of Some 2H- and 3H- Indole derivatives with ?-Cyclodextrins, Al-Sou’od, K. A., El-Barghouthi M. I., M, Zughul, M. B. and Badwan, A. A 12th International Cyclodextrin Symposium, Montpellier, France, May 16-19, Published Abstract, 2004.
11.	Application of  Percolation Theory on Compacts Utilized in Pharmaceutical Dosage forms, Eftatha, A. F. Remawi, M., El-Barghouthi M. I. and Badwan A. A. 6th Jordanian Chemical Conference, The Hashemite University. December 12, Published Abstract, 2005.
12.	Thermal Degradation of Para-Substituted Poly Styrenes in Solid Films and in Solutions, Alani K., El-Barghouthi M. I., Al-Buzzour M.A. A. 6th Jordanian Chemical Conference, The Hashemite University. December 12, Published Abstract, 2005.
13.	A Study Utilizing Percolation Theory: Mechanical Properties and Release Behavior of a Controlled Release System,  Eftatha, A. F., Remawi, M., El-Barghouthi M. I. and Badwan A. A. 6th  First Chemical Scientific Day, Mu’tah University, Jordan. April 26, Published Abstract, 2006.
14.	The Application of Percolation Theory on Binary Mixtures of Chitosan and Xanthan Gum,  Eftatha, A. F., Remawi, M., El-Barghouthi M. I., Rashid, I. S. and Badwan A. Jordan International Pharmaceutical Conference, Al-Zaytoonah University, Faculty of Pharmacy, Amman-Jordan. 15-17 November, Published Abstract, 2006.
15.	Molecular Dynamics Study of the Binding Affinity of Cucurbit[7]uril and ?-Cyclodextrin Toward  Cationic and Neutral Guest Molecules, K. Assaf, A. Rawashdeh, M.I. El-Barghouthi, The Fifth Jordanian International Conference of Chemistry, Chemistry Department  Yarmouk University, Irbid, Jordan, 17-19 June, Published Abstract, 2008.
16.	Syntheses, Crystallography and Spectroelectrochemical Studies of Ruthenium Azomethine Complexes, Mousa  Al-Noaimi, Haytham Saadeh, Salim F. Haddad, M. I. El-Barghouthi, Mohammad El-Khateeb and Robert J. Crutchley, The Fifth Jordanian International Conference of Chemistry, Chemistry Department  Yarmouk University, Irbid, Jordan, 17-19 June, Published Abstract, 2008.
17.	Synthesis, Characterization and DFT Calculation of Ruthenium (II) Azoimine-Diphosphine Mixed-Ligand Complexes, Mousa Al-Noaimi, M. I. El-Barghouthi, Mohammad El-Khateeb, Obada S. Abdel-Rahman, Helmar G?rls and Robert J. Crutchley, The Fifth Jordanian International Conference of Chemistry, Chemistry Department  Yarmouk University, Irbid, Jordan, 17-19 June, Published Abstract, 2008.
18.	Dynamics of Viologen-Cucurbituril Complexes in Aqueous Solution, K. Assaf, A. Rawashdeh, M.I. El-Barghouthi, The 9th Jordanian Chemical Conference, The Hashemite University, Zarqa, Jordan, 28 April, Published Abstract, 2009.

MUSA IBRAHIM MUSA ELBARGHOUTHI

MUSA IBRAHIM MUSA ELBARGHOUTHI

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